Prof. Dr. Abbas Naji Al-Shareeifi, President of Ibn Sina University of Medical and Pharmaceutical Sciences, participated as a supervisor in the committee for the PhD dissertation defence titled: " Serum Levels of MicroRNA-499-5p, Copeptin, and Cardiac Myosin-Binding Protein C for the Early Diagnosis and Differentiation of Acute Coronary Syndrome Types Compared to High-Sensitivity Cardiac Troponin I ", presented by the candidate Ali Abdulrasool Hussein in the Clinical Biochemistry specialization at the College of Medicine, Al-Mustansiriyah University. The defence committee was composed of: Prof. Dr. Abbas Naji Al-Shareeifi – President of Ibn Sina University of Medical and Pharmaceutical Sciences / Supervisor Prof. Dr. Abdul Kareem Hammadi Issa – Head of the Department of Chemistry and Biochemistry / Supervisor Prof. Dr. Mustafa Taha Mohammed – Chair Prof. Dr. Ikhlas Khalid Hameed – Member Prof. Dr. Maysa Jalal Majid – Member Asst. Prof. Dr. Eham Amer Ali – Member Asst. Prof. Dr. Abdul Ameer Jassim Jawad – Member The session was attended by Asst. Prof. Dr. Nebras Hatem Khamis, the vice Dean for Scientific Affairs, and Dr. Ameen Mohammed Kadhim, the Vice Dean for Administrative affairs, along with a distinguished group of professors, physicians, and postgraduate students. The dissertation addressed Acute Coronary Syndrome (ACS), which remains one of the leading causes of morbidity and mortality worldwide. The research emphasized the significance of early diagnosis in reducing complications associated with this condition. ACS manifests in three major subtypes based on electrocardiogram (ECG) findings: 1. ST-Elevation Myocardial Infarction (STEMI) 2. Non-ST-Elevation Myocardial Infarction (NSTEMI) 3. Angina The study aimed to Measure serum levels of MicroRNA-499-5p, Copeptin, and Myosin-Binding Protein C and compare them to High-Sensitivity Troponin I (hs-TnI) as biomarkers for early ACS detection. Investigate the correlation between these biomarkers and ACS complications as well as their relationship with cardiovascular risk factors. The key Findings of this study indicated that Serum levels of MicroRNA-499-5p, Copeptin, and Myosin-Binding Protein C were significantly elevated in various ACS subtypes compared to the control group. These markers demonstrated earlier and potentially more significant elevations than hs-TnI, suggesting their potential as early diagnostic tools for ACS. MicroRNA-499-5p showed the highest discriminatory ability in differentiating ACS patients from healthy individuals, as well as distinguishing between different ACS subtypes. The strong positive correlation between these biomarkers and hs-TnI levels in the myocardial infarction groups suggests their association with the severity of cardiac injury in ACS